Cancer is a major cause of morbidity and mortality worldwide, but a large proportion of the incidents are preventable. For example, mass-screening Nordic programs of cervical cancer have a proven strong effect for preventing cancer at the population level and have produced large amounts of individual and clinical data, centrally organised at nationwide registries. Despite this success, minimising over- and under-treatment, and, thus, reducing expenditure, remains a major challenge. Existing automatic decision support systems for cervical cancer prevention are, however, extremely conservative as they are mostly limited to identifying patients who are overdue for their next routine screening. Current knowledge about the cancer, together with a wealth of available data and modern technologies, can offer far better personalised prevention. DeCipher aims to develop a data-driven framework to provide a personalised time-varying risk assessment for cancer initiation and identify subgroups of individuals and biomarkers leading to similar disease progression. By unveiling structure hidden in the data via randomisation and probabilistic tools, we will develop novel theoretically grounded machine learning methods for analysis of temporal, sparse, and multimodal data. DeCipher consists of an excellent multidisciplinary research team from diverse fields such as machine learning, data mining, screening programs, and epidemiology. Leveraging Nordic screening programs and data, the project will enable better and more accurate cancer screening. Our foundational and algorithmic progress will also enable integration of data-driven techniques into biomedical domain, thus corresponding to the Medium-term Time Horizon objectives. Available to screening programs, clinicians, and individuals in the population, the DeCipher results will allow for improvement of individual’s preventive cancer healthcare while reducing the cost of screening programs.
Project leader: Valeriya Naumova
Category: Øvrige forskningsinstitutter
Institution: SIMULA METROPOLITAN CENTER FOR DIGITAL ENGINEERING AS