Antimicrobial resistance (AMR) is emerging as a major global threat to health care. The AMR challenge has escalated further the last 3 years. We propose a unified INTPART approach for research-based education in innovative preventive and therapeutic measures along with development of novel diagnostics to combat AMR. The AMR-PART partnership is formed by strong research groups in Norway with complementary and multidisciplinary expertise teamed up with outstanding international BRIC collaborators in South Africa, India, China and the US. The AMR-PART project addresses the nature and role of chromosomally mediated antibiotic resistance with Mtb and Ng as model organisms. Tuberculosis affects 1/3 of the world's population. The incidence of AMR is still emerging as a public health problem worldwide. The AMR-PART project builds on the hypothesis that the current epidemics are fuelled by the selection of adapted and resistant microbial variants, due to antibiotic treatment. As antibiotics apply selective pressure, we postulate that hypermutating strains are likely to emerge, perpetuating the selection of multidrug-resistant and extensively drug-resistant strains. Consequently, components induced under antibiotics-stress will be investigated as potential drug targets. Mutant libraries will be constructed and component collections will be screened in combination with rational drug design to discover novel inhibitors. Hits identified will be characterized for their mechanism of action. Advanced courses, workshops and training will be established for each step of the experimental plan required to reach these goals. The expected outcome will be a pipeline of educational tools facilitating knowledge on AMR, in line with UN sustainable development goals # 3, 4, 8, 9 and 17. The research-based education will facilitate novel diagnostics, drug targets and drug leads over-riding AMR, as well as capacity building and frontline research-based education in sustainable settings.
Project leader: Tone Tønjum
Institution: UNIVERSITETET I OSLO